Veza između pilula za kontracepciju sa visokim nivoom estrogena

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Istraživači su ustanovili vezu izmedju pilula za kontracepciju, sa visokim nivoom estrogena, koje su mnoge žene koristile decenijama, i zakrečenja arterija koje može da vodi do srčanih oboljenja. Medjutim, lekari naglašavaju da milioni žena trenutno koriste nove pilule sa manje estrogena i da ova nova studija ne znači da treba da prestanu da ih uzimaju.

Više od dve i po hiljade žena izmedju 35 i 55 godina učestvovao je u studiji. Istraživači su želeli da ustanove da li pilule za kontracepciju sa većim nivoom estrogena imaju bilo kakav uticaj na stvaranje naslaga u arterijama. U studiji nisu ispitivane pilule sa niskim nivom estrogena. Rezultat je bio povećanje od 20 do 30 odsto naslaga u arterijama za svakih 10 godina korišćenja pilula. I to je slučaj čak i kada su žene prestale da ih uzimaju. Belgijski kardiolog Ernst Rajtšil predvodio je istraživanje.

«Znali smo da je postojao rizik od stvaranja naslaga za vreme korišćenja pilula, ali takodje je bilo jasno da jednom kada prestanete da ih uzimate, više niste izloženi riziku. Medjutim, naši podaci ukazuju da ako uzimate pilule u dužem vremenskom periodu, imate nagomilavanje oštećenja koje vas izlaže riziku čak i kada prestanete da ih uzimate,» kaže doktro Rajtsšil.

Drugi kardiolozi tvrde da ova studija predstavlja  poziv na uzbunu za mnoge žene i njihove lekare. Dženifer Mieres je direktorka za nukleranu kardiologiju na Njujorškom univerzitetu.

«To nas podseća da srčana oboljenja počinju rano i veoma tiho. Većina žena i ne razmišlja o srčanim oboljenjima do svojih postmenopauznih godina.»

Doktorka Mieres kaže da žene koje uzimaju pilule za kontracepciju moraju da obrate pažnju i na ostale faktore rizika kao što su pušenje, visok krvni pritisak, holesterol, ishrana i vežbanje. Istraživači i drugi lekari pozivaju na izradu dodatnih studija o efektima pilula sa višim nivoom estrogena koje se danas koriste.

Voanews.com

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Nužan oprez pri uzimanju kontraceptivnih pilula
Autor: S. T. | Blic

Stručnjaci upozoravaju na to da je reproduktivnost nacije u Srbiji ugrožena i da devojke treba da koriste kontraceptivne pilule kako bi izbegle neželjenu trudnoću, ali ipak treba biti pažljiv u odabiru pilula i nikako ih uzimati bez saveta lekara. U Australiji je jedna studentkinja umrla zbog pilula za kontracepciju „Yasmin“, proizvođača „Bayer“, koje se koriste i u Srbiji.

Dvadesetčetvorogodišnja Tanja Hejs pilule je uzimala na preporuku lekara kao deo terapije, uz još jedan lek, zbog dugotrajnih problema sa aknama. Tokom četiri meseca korišćenja, ignorisala je simptome poput nestajanja daha i teškog kašlja, pa je odjednom i kolabirala. Pet sati kasnije umrla je zbog plućne embolije, to jest stvaranja krvnog ugruška u plućima. Australijski lekari su konstatovali da su krvni ugrušci uzrokovani faktorima povezanima s uzimanjem oralne kontracepcije.

- Tačno je da je venska tromboza neželjeni efekat kod korišćenja pilula za kontracepciju. Međutim, tromboza ne ubija momentalno. Da je kojim slučajem devojka po pojavi simptoma prestala da pije pilule, ništa joj se ne bi desilo - objašnjava za „Blic“ dr Ana Mitrović, ginekolog u GAK „Narodni front“ i predsednica Udruženja za reproduktivno zdravlje.
I u farmaceutskoj kompaniji „Bayer“, proizvođaču „Yasmin“ pilula za kontracepciju zbog kojih je devojka umrla, kažu da je u pitanju retko neželjeno dejstvo koje se može javiti pri korišćenju svih kontraceptivnih pilula. Venska tromboza je kao neželjeno dejstvo takođe naglašena u uputstvu za korišćenje kontraceptivnih pilula.
Jedna od ideja lekara, nastavlja dr Ana Mitrović, jeste da se pacijenti edukuju kako ništa ne bi radili na svoju ruku i kako bi bili u stanju da blagovremeno prepoznaju simptome. Bol u potkolenici, grudnom delu i bilo kakav problem s disanjem razlozi su zbog kojih se odmah treba javiti lekaru.
Kontraceptivne pilule sadrže najčešće dve vrste hormona (estrogen i progesteron) koji imaju za cilj da spreče ovulaciju kako bi ženu zaštitili od neželjene trudnoće.
- Pilule su nekad sadržale veću dozu hormona, koja je sada smanjena zbog rizika. Postoji mnogo pilula i svaka je različita. Potrebno je sa svakom pacijentkinjom razgovarati i uvidom u medicinsku dokumentaciju odlučiti šta je za nju efikasno i bezbedno - ističe dr Mitrović.
U Srbiji se ipak, kaže doktorka, pilule za kontracepciju najviše koriste u terapijske svrhe. Daju se pacijentkinjama koje treba da budu podvrgnute vantelesnoj oplodnji, za regulisanje menstrualnog ciklusa ili za smanjenje bola kod menstruacije. Takođe se koriste u terapiji i prevenciji cista na jajniku, ali i u kozmetičke svrhe kod problema sa kožom.

Rizik od venske tromboze
Kod žena koje ne koriste kontraceptivne pilule rizik od venske tromboze je 10 na 100.000. Ukoliko koriste pilule, verovatnoća za dobijanje venske tromboze je 20 do 40 žena, dok je rizik najveći kod trudnica i on iznosi 60 na 100.000 žena.

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Studentkinja iz Zadra umrla od antibebi pilula?
Autor: Srna | Blic

Studentkinja čiji su inicijali H.R. (22) iz Zadra navodno je umrla od plućne embolije izazvane pilulama za kontracepciju "jasmin", od kojih je nedavno preminula jedna devojka iz Australije, prenose hrvatski mediji.

H.R. je prvo pala u komu, a zatim preminula. Sahranjena je bez obdukcije, na zahtev roditelja, tako da je pod znakom pitanja hoće li se sa sigurnošću utvrditi da li su pilule uzrok smrti.

Farmaceutska kompanija ''Bajer'' juče je poslala upozorenje hrvatskim apotekama da su "jasmin" tablete rizične za korišćenje.
U tom dopisu su informacije u vezi s hormonskim kontraceptivom "jasmin", pilulom koja je od nedavno pod pažnjom javnosti nakon što je Tanja Hejs (24) u Australiji umrla od posledica izazvanih uzimanjem "jasmina".

blic

[ambrozija]

Drage kolege,
Yasmin proizvodi Schering a ne Bayer. Takvo saopste nema na njihovom sajtu.

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pa bayer schering je valjda jedna te ista firma?

http://www.reuters.com/article/rbssHealthcareNews/idUSWEB733220080303

http://www.bayerhealth.com/BayerHC/display.cfm?Object_ID=272&Article_ID=56&expandMenu_ID=

http://www.fiercepharma.com/story/bayer-loses-yasmin-patent-fight/2008-03-04

o samim Yasmin tabletama :

Yasmin

Generic Name: drospirenone and ethinyl estradiol (dro SPY re nown, ETH in il, ESS tra dy ol )
Brand Names: Yasmin, Yaz
What is Yasmin?
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Yasmin prevents ovulation (the release of an egg from an ovary) and also cause changes in your cervical and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.

Yasmin is used as contraception to prevent pregnancy. It is also used to treat moderate acne in women who are at least 14 years old and have started having menstrual periods, and who wish to use birth control pills to prevent pregnancy.

This medication is also used to treat the symptoms of premenstrual dysphoric disorder (PMDD), such as anxiety, depression, irritability, trouble concentrating, lack of energy, sleep or appetite changes, breast tenderness, joint or muscle pain, headache, and weight gain.

Yasmin may also be used for other purposes not listed in this medication guide.
Important information about Yasmin
This medication can cause birth defects in an unborn baby. Do not use if you are pregnant. Do not use Yasmin if you have any of the following conditions: a history of stroke or blood clot, circulation problems (especially if caused by diabetes), a heart valve disorder, breast or uterine cancer, abnormal vaginal bleeding, kidney or liver disease, an adrenal gland disorder, severe high blood pressure, migraine headaches, or a history of jaundice caused by birth control pills.
Before taking Yasmin
Do not take Yasmin if you are allergic to drospirenone or ethinyl estradiol, or if you have:

    *

      uncontrolled high blood pressure, migraine headaches, or a heart valve disorder;
    *

      a history of stroke, blood clot, or circulation problems of diabetes;
    * kidney or liver disease;
    *

      adrenal gland disorder;
    *

      unusual vaginal bleeding;
    *

      any type of breast, uterine, or hormone-dependent cancer; or
    *

      a history of jaundice caused by birth control pills.

Before using Yasmin, tell your doctor if you have any of the following conditions.

    *

      high blood pressure or heart disease;
    *

      high cholesterol or if you are overweight;
    *

      liver cancer;
    *

      gallbladder disease;
    *

      diabetes;
    *

      seizures or epilepsy; or
    *

      a history of depression, irregular menstrual cycles, or history of breast or uterine cancer.

FDA pregnancy category X. Yasmin can cause birth defects. Do not use Yasmin if you are pregnant. Tell your doctor right away if you become pregnant during treatment. The hormones in this medication can pass into breast milk and may harm a nursing baby. Yasmin may also slow breast milk production. Do not use if you are breast-feeding a baby. Drospirenone may raise potassium levels in your blood. Other medical conditions can also affect potassium levels, including liver disease, kidney disease, and adrenal gland disorders. Before using Yasmin, tell your doctor if you have any of these conditions.

How should I take Yasmin?

Take Yasmin exactly as it was prescribed for you. Do not take larger amounts, or take it for longer than recommended by your doctor. You will take your first pill on the first day of your period or on the first Sunday after your period begins (follow your doctor's instructions).

Take one pill every day, no more than 24 hours apart. When the pills run out, start a new pack the following day. Get your prescription refilled before you run out of pills completely.
You may have breakthrough bleeding. Tell your doctor if this bleeding continues or is very heavy.

If you need to have any type of medical tests or surgery, or if you will be on bed rest, you may need to stop using Yasmin for a short time. Any doctor or surgeon who treats you should know that you are using Yasmin.

Your doctor will need to see you on a regular basis while you are using Yasmin. Do not miss any appointments. Self-examine your breasts monthly to check for lumps while you are taking Yasmin.
Store Yasmin at room temperature away from moisture and heat.
What happens if I miss a dose?

Missing a pill increases your risk of becoming pregnant.

If you miss one"active" pill, take the dose as soon as you remember or take two pills at the time of your next regularly scheduled dose. You do not need to use backup birth control.

If you miss two"active" tablets in a row in week one or two, take two tablets each for the next two regularly scheduled doses (one missed tablet plus one regularly scheduled tablet for 2 days in a row). Use another form of birth control for at least 7 days following the missed tablets.

If you miss two "active" tablets in a row in week three, or if you miss three tablets in a row during any of the first 3 weeks, throw out the rest of the pack and start a new package on the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday.

On Sunday, throw out the rest of the pack and start a new pack of pills that same day. You may not have a period that month, but this is expected. However, if you miss your period 2 months in a row, call your doctor because you might be pregnant.

If you miss one of the reminder pills in week four, skip that dose and take the next one as directed.

If you miss a pill, you may become pregnant if you have sex in the 7 days after your missed pill. You MUST use another birth control method (such as condoms or spermicides) as a back-up for those 7 days.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much Yasmin. Overdose symptoms may include nausea, vomiting, or vaginal bleeding.
What should I avoid while taking Yasmin?
Do not smoke while using Yasmin, especially if you are older than 35. Smoking can increase your risk of blood clots, stroke, or heart attack caused by birth control pills.

Yasmin will not protect you from sexually transmitted diseases--including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.
Yasmin side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Yasmin and call your doctor at once if you have any of these serious side effects:

    *

      sudden numbness or weakness, confusion, pain behind the eyes, problems with vision, speech, or balance;
    *

      chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
    *

      a change in the pattern or severity of migraine headaches;
    *

      stomach pain, loss of appetite, jaundice (yellowing of the skin or eyes);
    *

      a breast lump; or
    *

      symptoms of depression (sleep problems, weakness, mood changes).

Less serious side effects may include:

    *

      breast pain, tenderness, or swelling;
    *

      freckles or darkening of facial skin, increased hair growth, or loss of scalp hair;
    *

      changes in weight or appetite, swelling of your hands or feet;
    *

      problems with contact lenses;
    *

      vaginal itching or discharge; or
    *

      changes in your menstrual periods.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.
What other drugs will affect Yasmin?

Some drugs can make Yasmin less effective, which may result in pregnancy. Other drugs may be affected by Yasmin. Before using Yasmin, tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Where can I get more information?

    * Your pharmacist can provide more information about Yasmin.

    * Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Yasmin only for the indication prescribed.
    * Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2008 Cerner Multum, Inc. Version: 3.08. Revision Date: 12/03/2007 3:10:29 PM.

http://www.drugs.com/yasmin.html

i zvanicna prezentacija yasmina sa bayerovog sajta (bayerhealth.com) -> http://www.yasmin.ca/

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nastavak sa naslovne ...

 Isti uzrok smrti konstatovan je i Tanji Hejs iz Australije, koja je tablete koristila zbog problema sa aknama.

Zvaničnih potvrda da je Helena Rukavina preminula zbog upotrebe kontraceptivnih pilula još nema, ali ginekolozi znaju da pacijentkinje koje koriste kontraceptivne pilule imaju veće šanse za duboku vensku trombozu.

"Činjenica je da upotrebom oralne kontracepcije može se povećati rizik od duboke venske tromboze", kaže ginekologinja klinike "Narodni front" u Beogradu Ana Mitrović.

"Uopšte u populaciji od 100.000 žena, 10 žena će oboleti od duboke venske tromboze. Ukoliko koristi neki vid kontracepcije na bazi hormona, opasnost za vensku trombozu raste 30 do 40 posto", kaže ona.

U Srbiji su se tablete "Jasmin" pojavile pre pet godina. I u predstavništvu farmaceutske kuće Bajer-Šering kažu da je je njihov lek bezbedan, što su potvrdile i nadležne agencije.

U Agenciji za kontrolu lekova kažu da su tablete prošle sve rigozne kontrole i da nema razloga za zabrinutost građana.

Doktorka Ana Mitrović upozorila je da do neželjenih efekata može da dođe ukoliko se tablete ne koriste po upustvu i bez prethodno obavljenih pregleda.

"Ne smemo pilulu uzimati na svoju ruku, zato što naša sestra, prijateljica ima doboro iskustvo sa nekim lekom. Pilulu sme da prepiše samo lekar koji je upoznat sa negativnim i neželjenim efektima ovog leka", kaže ona.

U Srbiji kontraceptivnu pilulu "Jasmin" koristi 3 odsto žena. Međutim, lekari ističu da osobe koje piju kontraceptivne pilule, a osete bolove u potkolenici ili grudima ili koje kašlju, a uzrok kašljanja nije infekcija, moraju obavezno da se jave lekaru.

b92

[Kamicak]

Hooray za prezervative, dole pilule!

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